This Dec. 31, 2009 photo shows the founders of SOMARK Innovations Inc. , Mark Pydynowski, left, and Ramos Mays, right, with their electronic ink tattoo device at their office in San Diego. The device ink tattoos onto the tails of laboratory mice. After just three years in Missouri, Pydynowski and Mays relocated their promising young firm to San Diego this past year. Like a fledgling flying from its nest, the birth, development and departure of SOMARK Innovations illustrates the challenges confronting Missouri as it contends for the high-tech jobs touted as the foundation of the future economy.